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(S)-C33

Names

[ CAS No. ]:
2066488-39-7

[ Name ]:
(S)-C33

[Synonym ]:
6-{[(1S)-1-(4-Chlorophenyl)ethyl]amino}-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
4H-Pyrazolo[3,4-d]pyrimidin-4-one, 6-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-1-cyclopentyl-1,5-dihydro-

Biological Activity

[Description]:

A novel potent, selective PDE9A inhibitor with IC50 of 11 nM, >45-fold selectivity over other PDE isoforms; shows better selectivity than (R)-C33 against PDE5.

[References]

References 1. Huang M, et al. Mol Pharmacol. 2015 Nov;88(5):836-45. View Related Products by Target Phosphodiesterase (PDE)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C18H20ClN5O

[ Molecular Weight ]:
357.837

[ Exact Mass ]:
357.135651

[ LogP ]:
2.70

[ Index of Refraction ]:
1.725

[ Storage condition ]:
-20°C

Related Compounds