HCV-IN-40

Names

[ CAS No. ]:
2087916-66-1

[ Name ]:
HCV-IN-40

Biological Activity

[Description]:

HCV-IN-40 (Compound 18c) is a potent, orally active hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.259, 0.434 and 0.069 μM against GT1a, GT1b and GT1b CES1 replicons[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection

[Target]

EC50: 0.069 μM (GT1b CES1), 0.259 μM (GT1a), 0.434 μM (GT1b)[1]


[In Vivo]

HCV-IN-40 (Compound 18c) (1 mg/kg) provides very high nucleotide triphosphate (TP) in dog liver[1].

[References]

[1]. Chris Krueger A, et al. Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus. Bioorg Med Chem. 2020 Jan 1;28(1):115208.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H26BrFN3O9P

[ Molecular Weight ]:
594.32

Related Compounds