hTG2 inhibitor VA4
Names
[ CAS No. ]:
2088001-23-2
[ Name ]:
hTG2 inhibitor VA4
Biological Activity
[Description]:
hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency; inhibits both the transamidation and GTP binding activity of hTG2 in a cellular context, inhibits epidermal cancer stem cell invasion with EC50 of 3.9 uM.
[References]
References 1. Akbar A, et al. J Med Chem. 2017 Sep 28;60(18):7910-7927. 2. Feola J, et al. Brain Res. 2017 Aug 1;1668:1-11. View Related Products by Target Other Targets
Chemical & Physical Properties
[ Molecular Formula ]:
C33H41N5O6S
[ Molecular Weight ]:
635.78