DKR-1051
Names
[ CAS No. ]:
2089053-14-3
[ Name ]:
DKR-1051
Biological Activity
[Description]:
A novel potent, subtype-selective sigma 2 receptor/PGRMC1 ligand with Ki of 61 nM, 9-fold selectivity over sigma 1 receptors (Ki=556 nM); modulates intracellular Ca2+ levels in human SK-N-SH neuroblastoma cells, relieves spared nerve injury-induced mechanical hypersensitivity in vivo.
[References]
References 1. Yi B, et al. J Neurochem. 2017 Feb;140(4):561-575. 2. Sahn JJ, et al. ACS Chem Neurosci. 2017 Aug 16;8(8):1801-1811. View Related Products by Target Sigma Receptor
Chemical & Physical Properties
[ Molecular Formula ]:
C24H26F3N
[ Molecular Weight ]:
385.474