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NAcM-COV

Names

[ CAS No. ]:
2089293-81-0

[ Name ]:
NAcM-COV

Biological Activity

[Description]:

NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays; shows highly selectivity with respect to other protein acetyl-amide-binding sites; inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.

[References]

References 1. Scott DC, et al. Nat Chem Biol. 2017 Aug;13(8):850-857. View Related Products by Target Ubiquitin-conjugating Enzyme (E2)

Chemical & Physical Properties

[ Molecular Formula ]:
C28H35F3N4O2

[ Molecular Weight ]:
516.609


Related Compounds