4-(BENZO[D]OXAZOL-2-YL)ANILINE

Names

[ CAS No. ]:
20934-81-0

[ Name ]:
4-(BENZO[D]OXAZOL-2-YL)ANILINE

[Synonym ]:
4-Benzoxazol-2-ylphenylamine
4-Benzooxazol-2-yl-phenylamine

Biological Activity

[Description]:

4-(Benzo[d]oxazol-2-yl)aniline is a potent antitumor agent. 4-(Benzo[d]oxazol-2-yl)aniline has inhibitory activity against mammary carcinoma cell lines[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

4-(Benzo[d]oxazol-2-yl)aniline (compound 5b) (0-100 μM; 7 days for MCF-7 and 10 days for MDA 468) has inhibitory activity against MCF-7 and MDA 468 mammary carcinoma cell lines[1]. Cell Proliferation Assay[1] Cell Line: MCF-7 and MDA 468 Concentration: 0-100 μM Incubation Time: 7 days for MCF-7 and 10 days for MDA 468 Result: Exhibited inhibitory activity against MCF-7 (IC50>0.01-0.1 μM) and MDA 468 (IC50>0.1-1 μM).

[References]

[1]. Shi DF, et al. Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. J Med Chem. 1996 Aug 16;39(17):3375-84.

Chemical & Physical Properties

[ Density]:
1.257g/cm3

[ Boiling Point ]:
361.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₀N₂O

[ Molecular Weight ]:
210.23100

[ Flash Point ]:
172.4ºC

[ Exact Mass ]:
210.07900

[ PSA ]:
52.05000

[ LogP ]:
3.65820

[ Vapour Pressure ]:
2.08E-05mmHg at 25°C

[ Index of Refraction ]:
1.682

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%