AY 254
Names
[ CAS No. ]:
2093408-03-6
[ Name ]:
AY 254
Biological Activity
[Description]:
AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.
[References]
1. Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521
Chemical & Physical Properties
[ Molecular Formula ]:
C30H49N9O6
[ Molecular Weight ]:
631.779