NVP-MELK8a hydrochloride
Names
[ CAS No. ]:
2096992-20-8
[ Name ]:
NVP-MELK8a hydrochloride
Biological Activity
[Description]:
NVP-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM; exhibits high selectivity with only 7 off-target kinases inhibited >85% against 456 kinases at 1 uM, Flt3 (IC50=0.18 uM), Haspin (IC50=0.19 uM), PDGFRα (IC50=0.42 uM); exhibits growth inhibition of MDA-MD-468 cells with IC50 of 0.11 uM, and increases cells harboring 4N DNA content.
[References]
References 1. Touré BB, et al. J Med Chem. 2016 May 26;59(10):4711-23. 2. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693. View Related Products by Target MELK
Chemical & Physical Properties
[ Molecular Formula ]:
C25H33ClN6O
[ Molecular Weight ]:
469.02212
[ Storage condition ]:
2-8℃