1-(2-PYRIMIDINYL) PIPERAZINE

Names

[ CAS No. ]:
20980-22-7

[ Name ]:
1-(2-PYRIMIDINYL) PIPERAZINE

[Synonym ]:
2-piperazin-1-yl-pyrimidine
2-(Piperazin-1-yl)pyrimidin
2-(piperazin-1-yl)pyrimidine
EINECS 244-135-5
Pyrimidine, 2-(1-piperazinyl)-
1-pp
PMPRZ
RARECHEM AH CK 0195
1-(2-Pyrimidinyl)piperazine
2-piperazinopyrimidine
2,6-DICHLORO-4-[4-(4-METHYLPHENYL)-1,3-THIAZOL-2-YL]PYRIDINE
2-(1-Piperazinyl)pyrimidine
1-PYRIMIDYL PIPERAZINE
2-Piperazinylpyrimidine
1-(2-Pyrimidyl)piperazine
MFCD00040742
1-(2-PYRIMIDINYL) PIPERAZINE
Buspirone Impurity 1

Biological Activity

[Description]:

2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558)[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
328.0±52.0 °C at 760 mmHg

[ Melting Point ]:
32-34°C

[ Molecular Formula ]:
C₈H₁₂N₄

[ Molecular Weight ]:
164.208

[ Flash Point ]:
152.1±30.7 °C

[ Exact Mass ]:
164.106201

[ PSA ]:
41.05000

[ LogP ]:
0.49

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.551

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV9702000

CHEMICAL NAME :: Pyrimidine, 2-(1-piperazinyl)-

CAS REGISTRY NUMBER :: 20980-22-7

BEILSTEIN REFERENCE NO. :: 0151178

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H12-N4

MOLECULAR WEIGHT :: 164.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 25,193,1991

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S24/25

[ RIDADR ]:
UN3259

[ WGK Germany ]:
3

[ RTECS ]:
UV9702000

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Intravenous buspirone for the prevention of postoperative nausea and vomiting.

Eur. J. Clin. Pharmacol. 68(11) , 1465-72, (2012)

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