rel-Zotatifin

Names

[ CAS No. ]:
2098191-54-7

[ Name ]:
rel-Zotatifin

Biological Activity

[Description]:

rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₉N₃O₅

[ Molecular Weight ]:
487.55

Related Compounds

rel-(1R,4E,pS)-Cyclooct-4-enol
Rel-(1S,3S,4S,5R)-2-(tert-butoxycarbonyl)-5-fluoro-2-azabicyclo[2.2.1]heptane-3-carboxylic acid
rel-(2S,2'R,3'R)-2(3-Hydroxy-2-methoxy-2,3-dihydrobenzofuran-3-yl)-2-methoxy-3(2H)-benzofuranon
rel-Benzyl (1R,3S)-3-hydroxycyclopentane-1-carboxylate
rel-Phenyl(3α*-phenyl-3-methyloxirane-2α*-yl) ketone
rel-(1R,2S,4S)-norbornan-2-ol
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
2-[2-(4-Methylphenyl)-3-oxo-2,3-dihydro-1H-pyrazol-4-yl]acetic acid
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
tert-Butyl (5-chloropentyl)carbamate
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine