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Thalidomide-O-PEG2-propargyl

Names

[ CAS No. ]:
2098487-52-4

[ Name ]:
Thalidomide-O-PEG2-propargyl

Biological Activity

[Description]:

Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

[References]

[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H20N2O7

[ Molecular Weight ]:
400.38

[ Storage condition ]:
-20°C

Related Compounds