CAM4066

Names

[ Name ]:
CAM4066

[Synonym ]:
N-[(2-Chloro-4-biphenylyl)methyl]-β-alanyl-N-(3-carboxyphenyl)-β-alaninamide
β-Alaninamide, N-[(2-chloro[1,1'-biphenyl]-4-yl)methyl]-β-alanyl-N-(3-carboxyphenyl)-
N-[(2-Chlorobiphenyl-4-Yl)methyl]-β-Alanyl-N-(3-Carboxyphenyl)-β-Alaninamide

Biological Activity

[Description]:

CAM4066 (CAM-4066) is a potent and selective CK2α inhibitor with Kd of 0.32 uM and IC50 of 0.37 uM, shows significantly improved selectivity compared to other CK2α inhibitors.

[References]

References 1. Iegre J, et al. Chem Sci. 2018 Feb 20;9(11):3041-3049. 2. Brear P, et al. Chem Sci. 2016 Nov 1;7(11):6839-6845. 3. De Fusco C, et al. Bioorg Med Chem. 2017 Jul 1;25(13):3471-3482. View Related Products by Target Casein Kinase

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
780.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₆ClN₃O₄

[ Molecular Weight ]:
479.955

[ Flash Point ]:
425.6±32.9 °C

[ Exact Mass ]:
479.161194

[ LogP ]:
4.30

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.630