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CYP11B1-IN-25

Names

[ CAS No. ]:
2101952-78-5

[ Name ]:
CYP11B1-IN-25

[Synonym ]:
3-Methoxy-5-[(3-phenyl-1,2-oxazol-5-yl)methyl]pyridine
Pyridine, 3-methoxy-5-[(3-phenyl-5-isoxazolyl)methyl]-

Biological Activity

[Description]:

CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2; inhibits rat CYP11B1 in V79MZ cells expressing recombinant rat CYP11B1 with IC50 of 1.8 uM; shows a high oral bioavailability (F = 50%) and sufficient plasma concentrations in rats, improved pharmacological profile for treatment of Cushing's disease.

[References]

References 1. Emmerich J, et al. J Med Chem. 2017 Jun 22;60(12):5086-5098. View Related Products by Target Cytochrome P450 (CYPs)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
455.6±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H14N2O2

[ Molecular Weight ]:
266.295

[ Flash Point ]:
229.4±27.3 °C

[ Exact Mass ]:
266.105530

[ LogP ]:
2.53

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.577

Related Compounds