AB-680

Names

[ Name ]:
AB-680

Biological Activity

[Description]:

AB-680 is highly potent, reversible and selective small molecule inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Ki: 4.9 pM (hCD73)[1] IC50: 43 pM (Soluble hCD73)[1]

[In Vitro]

AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].

[References]

[1]. Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄ClFN₄O₉P₂

[ Molecular Weight ]:
580.82

[ Storage condition ]:
2-8°C

AB-680

Names

Biological Activity

Chemical & Physical Properties

Related Compounds