CLK inhibitor T3

Names

[ Name ]:
CLK inhibitor T3

[Synonym ]:
4-[2-Methyl-1-(4-methyl-1-piperazinyl)-1-oxo-2-propanyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide
MFCD31689325
Benzamide, 4-[1,1-dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]-

Biological Activity

[Description]:

CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110 nM for CLK1,2 and 3, respectively; displays 200-300-fold selectivity over other dual specificity kinases such as DYRK1A and DYRK1B; induces dose-dependent reduction in exon recognition and exhibits an overlapping, but greater effect on transcriptome splicing compared to KH-CB19.

[References]

References 1. Funnell T, et al. Nat Commun. 2017 Feb 23;8(1):7. View Related Products by Target Cdc2-like Kinase (CLK)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₈H₃₀N₆O₂

[ Molecular Weight ]:
482.577

[ Exact Mass ]:
482.243011

[ LogP ]:
2.36

[ Index of Refraction ]:
1.659

CLK inhibitor T3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds