LY 392098

LY 392098 is a selective, potent and centrally active positive allosteric modulator of AMPAR; enhances glutamate (100 uM) stimulated ion influx through recombinant homomeric human AMPAR ion channels with EC50 of 1.77 uM (GluR1(i)), 0.22 uM (GluR2(i)), 0.56 uM (GluR2(o)), 1.89 uM (GluR3(i)) and 0.20 uM (GluR4(i); enhances a dose-dependent manner responses to AMPA, potentiates the synaptic excitation of dentate granule cells following perforant path stimulation in vivo.

References 1. Miu P, et al. Neuropharmacology. 2001 Jun;40(8):976-83. 2. Gates M, et al. Neuropharmacology. 2001 Jun;40(8):984-91. 3. Vandergriff J, et al. Neuropharmacology. 2001 Jun;40(8):1003-9. View Related Products by Target iGluR