NHWD-870

Names

[ Name ]:
NHWD-870

Biological Activity

[Description]:

NHWD-870 is a potent, orally active and selective BET family bromodomain and only binds bromodomains of BRD2, BRD3, BRD4 (IC50=2.7 nM), and BRDT. NHWD-870 has potent tumor suppressive efficacies and suppresses cancer cell-macrophage interaction. NHWD-870 increases tumor apoptosis and inhibits tumor proliferation.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₉N₇O

[ Molecular Weight ]:
491.59

Related Compounds

NRT-870-59
tetrasodium hydrogen bis[5-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]-4-hydroxy-3-[(2-hydroxy-5-nitrophenyl)azo]naphthalene-2,7-disulphonato(4-)]chromate(5-)
diethofencarb
N-Aminorhodanine
Staphylococcus aureus, lysate
Iron oxide brown
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
(E)-4-(3-chloro-4-methoxy-phenyl)but-3-en-2-one
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
4-[(But-3-yn-1-yl)amino]-3-methylbenzoic acid
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
Methy 4-amino-3-bromo-5-[(2-hydroxy-2-methylpropyl)amino]benzoate
5-ethyl-1-(2-methylphenyl)-1H-pyrazol-4-amine