Pa 155A

Names

[ Name ]:
Pa 155A

[Synonym ]:
[S-(R*,S*)]-5-[1-(1H-Indol-3-yl)ethyl]-2-(methylamino)-4(5H)-oxazolone
(1R,5S)-(-)-5-(1-Indol-3-ylethyl)-2-(methylamino)-2-oxazolin-4-one
(5S)-5-[(1R)-1-(1H-Indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4(5H)-one
Indolemycin
4(5H)-Oxazolone, 5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-, (5S)-
2-Methylamino-5a-(b-indolyl)ethyl-2-oxazolin-4-one
Pa 155A
indolmycin
2-Oxazolin-4-one,5-(1-indol-3-ylethyl)-2-(methylamino)-,(1R,5S)-(-)
4(5H)-Oxazolone,5-(1-(1H-indol-3-yl)ethyl)-2-(methylamino)-,(S-(R*,S*))
PA 155 A
5-(1-Indol-3-ylethyl)-2-(methylamino)-2-oxazolin-4-one
Indomycin
(5S)-5-[(1R)-1-(1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4-one

Biological Activity

[Description]:

Indolmycin (TAK-083), an antibiotic, is a competitive inhibitor of prokaryotic tryptophanyl-tRNA ligase (TrpS). Indolmycin (TAK-083) possesses both anti-viral and anti-bacterial activity[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Indolmycin was bacteriostatic and demonstrated good activity against MSSA (methicillinsusceptible Staphylococcus aureus), MRSA (methicillin-resistant S. aureus) and VISA (vancomycinintermediate S. aureus), including strains resistant to mupirocin or fusidic acid. Indolmycin MICs for 20 strains ranged from 8 to 32 mg/L, whereas asingle strain exhibited high-level resistance (MIC 128 mg/L)[2].

[References]

[1]. R G Werner, et al. Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase. Eur J Biochem. 1976 Sep;68(1):1-3.

[2]. Julian G Hurdle, et al. Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. J Antimicrob Chemother. 2004 Aug;54(2):549-52.

[3]. M R Harnden, et al. Thiazolinone analogues of indolmycin with antiviral and antibacterial activity. J Med Chem. 1978 Jan;21(1):82-7.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
420.8±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₅N₃O₂

[ Molecular Weight ]:
257.288

[ Flash Point ]:
208.3±26.5 °C

[ Exact Mass ]:
257.116425

[ PSA ]:
69.97000

[ LogP ]:
1.53

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.670

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%