RTICBM-74
Names
[ CAS No. ]:
2130881-32-0
[ Name ]:
RTICBM-74
Biological Activity
[Description]:
RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays.RTICBM-74 displays excellent half-life and low clearance against rat liver microsomes and hepatocytes, and excellent brain penetrance in rats.RTICBM-74 specifically reduces alcohol intake across a range of doses in male or female Wistar or Long-Evans rats, reduces alcohol intake and does not affect locomotion or sucrose self-administration.
[References]
1. Nguyen T, et al. J Med Chem. 2017 Sep 14;60(17):7410-7424. 2. Lovelock DF, et al. J Pharmacol Exp Ther. 2022 Mar;380(3):153-161.
Chemical & Physical Properties
[ Molecular Formula ]:
C19H14ClFN2O
[ Molecular Weight ]:
340.782