Kojibiose

[Description]:

Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium, lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo[1][2].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[In Vivo]

曲二糖 (0.5 %; w/w 每日摄入饮食; 持续 20 天) 显着改善花生酸 (ARa; 饮食每天 0.3 mg; 持续 20 天) 诱导的肝脏改变的严重程度[1]。 Animal Model: Female Wistar albino rats, aged 3 weeks with Streptozotocin (STZ; HY-13753) two doses of 25 mg/kg per d with a time lapse of 24 h[1] Dosage: 0.5%, w/w Administration: Diet; daily for 20 d Result: Significantly improved the severity of arachidic acid (ARa; 0.3 mg daily for 20 d)-induced hepatic alterations. Significantly increased expression values of PPAR α in comparison with those fed only ARa, suggesting an increased fatty acid metabolism. Showed reduced LPC and PS values than did animals fed only ARa.

[References]

[1]. José Moisés Laparra, et al. Kojibiose ameliorates arachidic acid-induced metabolic alterations in hyperglycaemic rats. Br J Nutr. 2015 Nov 14;114(9):1395-402.

[2]. Miaomiao Wang, et al. Cloning and expression of the sucrose phosphorylase gene in Bacillus subtilis and synthesis of kojibiose using the recombinant enzyme. Microb Cell Fact. 2018 Feb 15;17(1):23.

[ Density]:
1.68g/cm3

[ Boiling Point ]:
783.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₂₂O₁₁

[ Molecular Weight ]:
342.29600

[ Flash Point ]:
292.1ºC

[ Exact Mass ]:
342.11600

[ PSA ]:
189.53000

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.652

[ Storage condition ]:
-20°C

Click to get detail MSDS

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

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