K 22

ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i); inhibits several members of the family Flaviviridae, blocks replication of ZIKV, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), as well as to a certain extent, Usutu virus (USUV), Wesselsbron virus (WESSV), HCV and bovine viral diarrhea virus (BVDV) with IC50s <10 uM; act on early post-entry stages of coronavirus replication and to target membrane-bound viral RNA synthesis.

References 1. García-Nicolás O, et al. Antimicrob Agents Chemother. 2018 Sep 4. pii: AAC.01206-18. View Related Products by Target Filovirus