o-Chloroacetophenone

Names

[ Name ]:
o-Chloroacetophenone

[Synonym ]:
1-(2-Chlorophenyl)ethanone
Acetophenone,2'-chloro
2’-Chloroacetophenone
o-Chloroacetophonone
Ethanone, 1- (2-chlorophenyl)-
2′-Chloroacetophenone
o-Chloroacetophenone
acetophenone, 2'-chloro-
o-chlorophenyl methyl ketone
EINECS 218-397-6
2'-Chloroacetophenone
2‘-Chloroacetophenone
MFCD00000560
Ethanone, 1-(2-chlorophenyl)-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
195.5±13.0 °C at 760 mmHg

[ Melting Point ]:
52-56ºC

[ Molecular Formula ]:
C₈H₇ClO

[ Molecular Weight ]:
154.594

[ Flash Point ]:
89.6±11.0 °C

[ Exact Mass ]:
154.018539

[ PSA ]:
17.07000

[ LogP ]:
2.09

[ Vapour Pressure ]:
0.4±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.532

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM6310000

CHEMICAL NAME :: Acetophenone, 2'-chloro-

CAS REGISTRY NUMBER :: 2142-68-9

BEILSTEIN REFERENCE NO. :: 1858916

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H7-Cl-O

MOLECULAR WEIGHT :: 154.60

WISWESSER LINE NOTATION :: GR BV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CroHP# Personal Communication from H.P. Crocker, Ultimate Holding Co.-Reckitt & Colman Ltd., London, UK, Sept. 2, 1980 Volume(issue)/page/year: 02SEPT1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 880 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CroHP# Personal Communication from H.P. Crocker, Ultimate Holding Co.-Reckitt & Colman Ltd., London, UK, Sept. 2, 1980 Volume(issue)/page/year: 02SEPT1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7952 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39-S45-S36/37/39-S28A

[ RIDADR ]:
UN 3416 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
AM6310000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

[Saccharomyces cerevisiae B5 efficiently and stereoselectively reduces 2'-chloroacetophenone to R-2'-chloro-1-phenylethanol in the presence of 5% ethanol].

Sheng Wu Gong Cheng Xue Bao 19(2) , 206-11, (2003)

(R)-chlorprenaline, a selective activator of beta2 receptor and an effective drug for bronchitis and asthma, is industrially prepared from (R)-2'-chloro-1-phenyl-ethanol. In this communication, we des...

Spectral differentiation and gas chromatographic/mass spectrometric analysis of the lacrimators 2-chloroacetophenone and o-chlorobenzylidene malononitrile.

J. Forensic Sci. 31(2) , 658-65, (1986)

2-Chloroacetophenone (CN) and o-chlorobenzylidene malononitrile (CS) are the most common chemical agents used as lacrimators in the United States. There is a lack of complete spectral data on these co...

Improving the enantioselective bioreduction of aromatic ketones mediated by Aspergillus terreus and Rhizopus oryzae: the role of glycerol as a co-solvent. Andrade LH, et al.

Tetrahedron Asymmetry 20(13) , 1521-25, (2009)