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Zalifrelimab

Names

[ CAS No. ]:
2148321-69-9

[ Name ]:
Zalifrelimab

Biological Activity

[Description]:

Zalifrelimab (AGEN1884) is a fully human IgG1 monoclonal antibody targeting CTLA-4 (CTLA-4). Zalifrelimab antagonizes the inhibitory checkpoints of immune cell activation regulated by CTLA-4 signaling[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Zalifrelimab（AGEN1884；0.1、1、10 或 100 μg/mL）有效增强抗原特异性 T 细胞反应性，可与其他免疫调节抗体联合使用。Zalifrelimab 与 PD-1 阻断剂有效结合，可在外周引起 T 细胞增殖反应[2]。

[In Vivo]

Zalifrelimab（AGEN1884；10 mg/kg；静脉注射；第 1 天和第 29 天）在非人灵长类动物中具有良好的耐受性，可增强疫苗介导的抗原特异性免疫[2]。 Animal Model: Cynomolgus macaques (Macaca fascicularis)[2] Dosage: 10 mg/kg Administration: i.v.; on days 1 and 29 Result: Enhanced antigen-specific immune responses in combination with reporter vaccines in vivo.

[References]

[1]. David M O'Malley, et al. Dual PD-1 and CTLA-4 Checkpoint Blockade Using Balstilimab and Zalifrelimab Combination as Second-Line Treatment for Advanced Cervical Cancer: An Open-Label Phase II Study. J Clin Oncol. 2022 Mar 1;40(7):762-771.  

[2]. Randi B Gombos, et al. Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody. PLoS One. 2018 Apr 4;13(4):e0191926.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds