Sulfotransferase-IN-1
Names
[ CAS No. ]:
2158198-77-5
[ Name ]:
Sulfotransferase-IN-1
Biological Activity
[Description]:
The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM ; displays 8- to 18-fold greater specificity for GAG sulfotransferases compared to cytosolic sulfotransferases; decreases chondroitin sulfate-E (CS-E) and overall sulfation levels on cell-surface and secreted chondroitin sulfate proteoglycans (CSPGs), and reverses CSPG-mediated inhibition of axonal growth.
[References]
References 1. Cheung ST, et al. ACS Chem Biol. 2017 Dec 15;12(12):3126-3133. View Related Products by Target Other Targets
Chemical & Physical Properties
[ Molecular Formula ]:
C17H11BrCl2N2O3
[ Molecular Weight ]:
442.09
Safety Information
[ Hazard Codes ]:
Xi