Sulfotransferase-IN-1

Names

[ Name ]:
Sulfotransferase-IN-1

Biological Activity

[Description]:

The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM ; displays 8- to 18-fold greater specificity for GAG sulfotransferases compared to cytosolic sulfotransferases; decreases chondroitin sulfate-E (CS-E) and overall sulfation levels on cell-surface and secreted chondroitin sulfate proteoglycans (CSPGs), and reverses CSPG-mediated inhibition of axonal growth.

[References]

References 1. Cheung ST, et al. ACS Chem Biol. 2017 Dec 15;12(12):3126-3133. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₁BrCl₂N₂O₃

[ Molecular Weight ]:
442.09

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

LDH-IN-1
eIF4E-IN-1
CLK1-IN-1
DUBs-IN-1
HCVP-IN-1
HAT-IN-1
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine