SHP2-IN-2

Names

[ Name ]:
SHP2-IN-2

Biological Activity

[Description]:

SHP2-IN-2 is a selective, allosteric inhibitor of protein tyrosine phosphatase SHP2, preferentially inhibits SHP2 F285S over the PTP domain and allosteric site mutant; reduces the viability of MOLM14 cells with IC50 of 85 uM.

[References]

References 1. LaRochelle JR, et al. Bioorg Med Chem. 2017 Dec 15;25(24):6479-6485. View Related Products by Target Protein Phosphatase/PTP

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₁ClN₂O₂S

[ Molecular Weight ]:
342.797

Related Compounds

SHP2 IN-1
SHP2-IN-6
Vociprotafib
SHP2-IN-8
SHP2-IN-6 hydrochloride
NEP-IN-2
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
[2-Amino-1-(2-chloro-6-fluorophenyl)ethyl]dimethylamine dihydrochloride
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide