SOD1-Derlin-1 inhibitor 56-59

SOD1-Derlin-1 inhibitor 56-59 is a cell-permeable, small molecule inhibitor of SOD1-Derlin-1 interaction, target SOD1 DBR and clearly attenuates the interactions of Derlin-1 with 122 types of SOD1mut in the cell-based co-immunoprecipitation assay; significantly ameliorates the ALS pathology both in motoneurons derived from patient induced pluripotent stem cells and in model mice.

References 1. Tsuburaya N, et al. Nat Commun. 2018 Jul 10;9(1):2668. View Related Products by Target Other Targets