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Nidanilimab

Names

[ CAS No. ]:
2171061-85-9

[ Name ]:
Nidanilimab

Biological Activity

[Description]:

Nidanilimab (CAN04) is a fully humanized monoclonal anti-IL1RAP antibody with a Kd value of 1.10 pM. Nidanilimab blocks IL1α and IL1β signaling and stimulates the immune system to destroy tumour cells. Nidanilimab can be used in research of non-small lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) [1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

[Target]

IL-1α

IL-1β


[In Vitro]

Nidanilimab (CAN04; 20 µg/mL; 小鼠 MC38 结肠癌细胞) 具有糖工程介导增强的抗体依赖性细胞毒性 (ADCC, EC50<1 nM)[2]。 Nidanilimab (20 µg/mL; 小鼠 MC38 结肠癌细胞) 阻断 IL1α 和 IL1β 信号通路，IC50 值分别为 3.9 nM和 4.1 nM[2]。

[In Vivo]

Nidanilimab (CAN04; 10 mg/kg; i.p.; 裸 C57Bl/6 小鼠) 增加了两种常用的铂基化疗药物顺铂 (HY-17394)/吉西他滨 (HY-17026) 和卡铂 (HY-17393)/吉西他滨 (HY-17026) 的疗效[1]。 Animal Model: Nude C57Bl/6 mice with LU2503 NSCLC PDX model[1] Dosage: 10 mg/kg Administration: Intraperitoneal injection Result: Displayed a significantly stronger anti-tumor effect compared to isotype control with chemotherapy.

[References]

[1]. Millrud CR, et, al. The anti-IL1RAP antibody CAN04 increases tumor sensitivity to platinum-based chemotherapy.

[2]. Rydberg Millrud C, et, al. Blockade of IL-1α and IL-1β signaling by the anti-IL1RAP antibody nadunolimab (CAN04) mediates synergistic anti-tumor efficacy with chemotherapy. Cancer Immunol Immunother. 2022 Aug 29.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds