PNU112455A hydrochloride

Names

[ Name ]:
PNU112455A hydrochloride

[Synonym ]:
4-[(6-amino-4-pyrimidinyl)amino]-benzenesulfonamide hydrochloride

Biological Activity

[Description]:

PNU112455A hydrochloride is an ATP-competitive CDK2 and CDK5 inhibitor. PNU112455A hydrochloride binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively [1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK2:3.6 μM (Km)

CDK5:3.2 μM (Km)

[References]

[1]. Clare PM, et al. The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism. J Biol Chem. 2001 Dec 21;276(51):48292-9.

Chemical & Physical Properties

[ Density]:
1.532g/cm3

[ Boiling Point ]:
568.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂ClN₅O₂S

[ Molecular Weight ]:
301.75300

[ Flash Point ]:
297.7ºC

[ Exact Mass ]:
301.04000

[ PSA ]:
132.37000

[ LogP ]:
3.68710

[ Vapour Pressure ]:
6.04E-13mmHg at 25°C

[ Index of Refraction ]:
1.697

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%