BMS-905

Names

[ CAS No. ]:
2205846-49-5

[ Name ]:
BMS-905

Biological Activity

[Description]:

BMS-905 is a potent dual inhibitor of TLR7 and TLR8 with IC50 of 0.3 nM (TLR7, IL-6 inhibition in mouse blood), shows good selectivity against TLR9 and other TLR family members.

[References]

1. Ratna Kumar Sreekantha, et al. ACS Medicinal Chemistry Letters. DOI: 10.1021/acsmedchemlett.2c00049

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₉N₃

[ Molecular Weight ]:
347.506

Related Compounds

BMS-P5
BMS-8
BMS-538203
BMS-794833
BMS-779788
BMS-833923
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
5,8-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoxaline
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide