LIMK1 and 2 dual inhibitor
Names
[ CAS No. ]:
2215049-71-9
[ Name ]:
LIMK1 and 2 dual inhibitor
Biological Activity
[Description]:
LIMK1 and 2 dual inhibitor is a potent, selective LIMK1/2 inhibitor with IC50 of <10 nM for both, 15-fold selectivity over B-Raf (IC50=10-100 nM); inhibits p-c-ofilin at Ser3 site, suppresses cell proliferation of MV-411 cell of with IC50 of 1-5 uM.
[References]
References 1. US Patent WO 2018055097. View Related Products by Target LIM Kinase (LIMK)
Chemical & Physical Properties
[ Molecular Formula ]:
C28H21F3N6O3S2
[ Molecular Weight ]:
610.63