Seriniquinone

A melanoma-selective anticancer agent (IC50=30 nM, Malme-3M cell line), induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; demonstrates potent activity over a select set of tumor cell lines with particular selectivity toward melanoma cell lines; increases the cleavage of caspases 3, 7, and 9 and PARP in HCT-116 cells; causes an increasing level of DCD expression directly correlated with cell line selectivity,

References 1. Trzoss L, et al. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14687-92. 2. Matsuoka M, et al. J Heterocycl Chem. 1991;28(5):1445–1447. View Related Products by Target Other Targets