SNIPER(ABL)-058

Names

[ CAS No. ]:
2222354-61-0

[ Name ]:
SNIPER(ABL)-058

Biological Activity

[Description]:

SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

[References]

[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Chemical & Physical Properties

[ Molecular Formula ]:
C62H75N11O9S

[ Molecular Weight ]:
1150.39

Related Compounds