4-(N-(Butylcarbamoyl)sulfamoyl)benzoic acid

Names

[ CAS No. ]:
2224-10-4

[ Name ]:
4-(N-(Butylcarbamoyl)sulfamoyl)benzoic acid

[Synonym ]:
Carboxytolbutamide
N-Butyl-N'-(4-carboxyphenylsulfonyl)urea
4-(butylcarbamoylsulfamoyl)benzoic acid

Chemical & Physical Properties

[ Density]:
1.337g/cm3

[ Melting Point ]:
210-212ºC

[ Molecular Formula ]:
C₁₂H₁₆N₂O₅S

[ Molecular Weight ]:
300.33100

[ Exact Mass ]:
300.07800

[ PSA ]:
120.95000

[ LogP ]:
3.03540

[ Index of Refraction ]:
1.558

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
41

[ Safety Phrases ]:
26-39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 871(1) , 78-89, (2008)

A reliable liquid chromatography/tandem mass spectrometry has been developed for simultaneous evaluation of the activities of five cytochrome P450s (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A) in rat ...

Cytochrome P450 2C9 phenotyping using low-dose tolbutamide.

Eur. J. Clin. Pharmacol. 60(3) , 165-71, (2004)

The hypoglycaemic drug tolbutamide is used for assessment of CYP2C9 activity in vivo. However, therapeutically active doses of 500 mg bear the risk of hypoglycaemia, and a tolbutamide-derived paramete...

Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection.

Ther. Drug Monit. 21(6) , 664-71, (1999)

An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the oral antidiabetic tolbutamide and two of its metabolites, 4-hydroxytolbutamide and ...