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terbuthylazine d5

Names

[ CAS No. ]:
222986-60-9

[ Name ]:
terbuthylazine d5

[Synonym ]:
6-Chloro-N-(H)ethyl-N'-(2-methyl-2-propanyl)-1,3,5-triazine-2,4-diamine
1,3,5-Triazine-2,4-diamine, 6-chloro-N-(1,1-dimethylethyl)-N-(ethyl-d)-
N-tert-Butyl-6-chloro-N'-(H)ethyl-1,3,5-triazine-2,4-diamine

Biological Activity

[Description]:

Terbuthylazine-d5 is the deuterium labeled Terbuthylazine[1]. Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide[2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Cedergreen N, et al. Does the effect of herbicide pulse exposure on aquatic plants depend on Kow or mode of action? Aquat Toxicol. 2005 Feb 10;71(3):261-271.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
373.1±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H11ClD5N5

[ Molecular Weight ]:
234.741

[ Flash Point ]:
179.4±23.2 °C

[ Exact Mass ]:
234.140808

[ PSA ]:
62.73000

[ LogP ]:
2.98

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.594

Related Compounds