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5,6-trans-Vitamin D3

Names

[ CAS No. ]:
22350-41-0

[ Name ]:
5,6-trans-Vitamin D3

[Synonym ]:
(3S,5E,7E)-9,10-Secocholesta-5,7,10-trien-3-ol

Biological Activity

[Description]:

5,6-trans-Vitamin D3 (5,6-trans-Cholecalciferol;5,6-trans-Colecalciferol) is a photoproduct of vitamin D3[1]. Vitamin D3 is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

[Related Catalog]:

Signaling Pathways >> Vitamin D Related >> VD/VDR
Research Areas >> Metabolic Disease

[In Vitro]

Normal human keratinocytes in the cultured human keratinocytes by determining their influence on 3H-thymidine incorporation into DNA. 5,6-trans-vitamin D3 only induces significant inhibition at 10(-6) M. The dissociation constants of vitamin D receptor (VDR) for 5,6-trans-vitamin D3 is 560 nM[1].

[References]

[1]. T C Chen, et al. An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3. J Nutr Biochem. 2000 May;11(5):267-72.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H44O

[ Molecular Weight ]:
384.63800

[ Exact Mass ]:
384.33900

[ PSA ]:
20.23000

[ LogP ]:
7.61900

Related Compounds