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garenoxacin mesylate

Names

[ CAS No. ]:
223652-82-2

[ Name ]:
garenoxacin mesylate

[Synonym ]:
Garenoxacin Mesilate

Biological Activity

[Description]:

Garenoxacin (BMS 284756) mesylate is an orally active quinolone antibiotic and Garenoxacin mesylate has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes. Garenoxacin mesylate also inhibits Gyrase and TOPO IV[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

1.25 μg/mL (Gyrase), 1.5-2.5 μg/mL (TOPO IV)[2]


[References]

[1]. Waites KB, et al. In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob Agents Chemother. 2003 Jan;47(1):161-5.  

[2]. Ince D, et al. Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone. Antimicrob Agents Chemother. 2002 Nov;46(11):3370-80.  

[3]. Zhao X, et al. Mutant prevention concentration of garenoxacin (BMS-284756) for ciprofloxacin-susceptible or -resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2003 Mar;47(3):1023-7.  

[4]. Azoulay-Dupuis E, et al. Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model. Antimicrob Agents Chemother. 2004 Mar;48(3):765-73.  

Chemical & Physical Properties

[ Density]:
1.421g/cm3

[ Boiling Point ]:
581.5ºC at 760mmHg

[ Molecular Formula ]:
C24H24F2N2O7S

[ Molecular Weight ]:
522.52

[ Flash Point ]:
305.5ºC

[ Exact Mass ]:
522.12700

[ PSA ]:
143.31000

[ LogP ]:
5.38080

Related Compounds