DMA-135 freebase
Names
[ CAS No. ]:
2237925-61-8
[ Name ]:
DMA-135 freebase
Biological Activity
[Description]:
DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.DMA-135 inhibits EV71 replication by attenuating IRES-dependent translation at dosages of relatively low cellular toxicity.DMA-135 changes the local and global structure of the EV71 SLII IRES domain.DMA-135 allosterically stabilizes a AUF1 (cellular protein)-SLII-(DMA-135) ternary complex.
[References]
1. Jesse Davila-Calderon, et al. Nat Commun. 2020 Sep 22;11(1):4775.
Chemical & Physical Properties
[ Molecular Formula ]:
C16H17N7O
[ Molecular Weight ]:
323.360