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3-Phosphoglyceric acid barium

Names

[ CAS No. ]:
22457-55-2

[ Name ]:
3-Phosphoglyceric acid barium

[Synonym ]:
{2-Hydroxy-3-[(phosphono-κO,O')oxy]propanoato(2-)}barium
3-PHOSPHO-D-GLYCERIC ACID BARIUM SALT
Barium, [2-hydroxy-3-[(phosphono-κO,κO')oxy]propanoato(2-)]-
BARIUM 3-PHOSPHO-D-GLYCERATE DIHYDRATE
barium 3-phospho-d-glycerate
Einecs 245-012-9
3-Phospho-D-glyceric Acid BariuM Salt Dihydrate

Biological Activity

[Description]:

3-Phosphoglyceric acid barium is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid barium is involved in alveolar macrophage epigenetic regulation[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

3-Phosphoglyceric acid (400 µM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed[1]. 3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages[1]. In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation[1]. RT-PCR[1] Cell Line: Bone marrow-derived macrophages (BMDMs) Concentration: 400 µM Incubation Time: 24 hours Result: Enhanced Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification was also reversed.

[References]

[1]. Zhang W, et al. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018 Dec 3;215(12):3180-3193.

Chemical & Physical Properties

[ Boiling Point ]:
536.6ºC at 760mmHg

[ Molecular Formula ]:
C3H5BaO7P

[ Molecular Weight ]:
321.368

[ Flash Point ]:
278.3ºC

[ Exact Mass ]:
321.882538

[ PSA ]:
246.20000

[ Vapour Pressure ]:
9.37E-14mmHg at 25°C

MSDS

Click to get detail MSDS

Preparation


Related Compounds