β-Glucuronide-dPBD-PEG5-NH2

Names

[ CAS No. ]:
2246363-68-6

[ Name ]:
β-Glucuronide-dPBD-PEG5-NH2

Biological Activity

[Description]:

β-Glucuronide-dPBD-PEG5-NH2 is the β-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD. β-glucuronide-linkage as a cleavable linker. β-Glucuronide-dPBD-PEG5-NH2, as a prodrug of cIRCR201-dPBD, reduces side effects[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Drug-linker conjugates for ADC, Apoptosis[1]


[References]

[1]. Byeongkwi Min, et al. cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors. ACS Omega. 2020 Sep 29;5(40):25798-25809.

Chemical & Physical Properties

[ Molecular Formula ]:
C78H101N7O35

[ Molecular Weight ]:
1696.66

Related Compounds