Liproxstatin-1 hydrochloride

Names

[ Name ]:
Liproxstatin-1 hydrochloride

Biological Activity

[Description]:

Liproxstatin-1 hydrochloride is a high-potency ferroptosis inhibitor capable of effectively preventing ferroptotic cell death, with an IC50 value of 22 nM [1].

[In Vitro]

Liproxstatin-1 shows antiferroptotic activity with an IC 50 of approximately 38 nM in mouse embryonic fibroblasts [2].

[In Vivo]

Liproxstatin-1 (10 mg/kg, i.p.) suppresses ferroptosis in human cells, Gpx4 -/- kidney and in an ischaemia/reperfusion-induced tissue injury model [1].

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₂Cl₂N₄

[ Molecular Weight ]:
377.31