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Symphytine

Names

[ CAS No. ]:
22571-95-5

[ Name ]:
Symphytine

[Synonym ]:
myoporoside
(1R,7aR)-7-{[(2,3-Dihydroxy-2-isopropylbutanoyl)oxy]methyl}-2,3,5 ,7a-tetrahydro-1H-pyrrolizin-1-yl (2E)-2-methyl-2-butenoate
myoscorpine
Ajugol

Biological Activity

[Description]:

Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vivo]

Symphytine (intraperitoneal injection; 13 mg/kg; 330 days) leads to survival for more than 330 days after the start of injections. Four of 20 rats (20%) had liver tumors: three has hemangioendothelial sarcoma and 1 has liver cell adenoma[1]. Animal Model: Male inbred ACI rats[1] Dosage: 13 mg/kg Administration: Intraperitoneal injection; 330 days Result: Led to hepatic tumor in rats.

[References]

[1]. Hirono,et al.Induction of Hepatic Tumors in Rats by Senkirkine and Symphytine. J Natl Cancer Inst. 1979 Aug;63(2):469-72.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H31NO6

[ Molecular Weight ]:
381.46300

[ Exact Mass ]:
381.21500

[ PSA ]:
96.30000

[ LogP ]:
1.12770

Safety Information

[ RIDADR ]:
UN 1544

Related Compounds