QC-01–175
Names
[ CAS No. ]:
2267290-96-8
[ Name ]:
QC-01–175
Biological Activity
[Description]:
QC-01-175 is a hetero-bifunctional molecule designed to engage both tau and Cereblon (CRBN) to trigger tau ubiquitination and proteasomal degradation (tau PROTAC).QC-01–175 effected clearance of tau in frontotemporal dementia (FTD) patient-derived neuronal cell models, with minimal effect on tau from neurons of healthy controls.QC-01–175 also rescued stress vulnerability in FTD neurons, phenocopying CRISPR-mediated MAPT-knockout.
[References]
1. M Catarina Silva, et al. Elife. 2019 Mar 25;8:e45457.
Chemical & Physical Properties
[ Molecular Formula ]:
C33H34N6O7
[ Molecular Weight ]:
626.670