(S)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate
Names
[ CAS No. ]:
228244-04-0
[ Name ]:
(S)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate
[Synonym ]:
2-Methyl-2-propanyl (2S)-2-cyano-1-pyrrolidinecarboxylate
(s)-1-n-boc-2-cyanopyrrolidine
S-(-)-1-Boc-2-pyrrolidinecarbonitrile
MFCD01861225
N-tert-butyloxycarbonyl proline nitrile
(S)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
307.9±35.0 °C at 760 mmHg
[ Melting Point ]:
33-36ºC
[ Molecular Formula ]:
C10H16N2O2
[ Molecular Weight ]:
196.246
[ Flash Point ]:
140.0±25.9 °C
[ Exact Mass ]:
196.121185
[ PSA ]:
53.33000
[ LogP ]:
0.40
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.489
[ Storage condition ]:
0-10°C
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
26-36/37/39
[ RIDADR ]:
UN 3439
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Med. Chem. 46 , 4543, (2003)
Isophthalic acid bis(l-prolyl-pyrrolidine) amide is a very potent prolyl oligopeptidase inhibitor, but it has a log P value of -0.2, which is very low for a compound targeted to the brain. Therefore, ...
Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors.J. Med. Chem. 52 , 6672-84, (2009)
Prolyl oligopeptidases cleave peptides on the carboxy side of internal proline residues and their inhibition has potential in the treatment of human brain disorders. Using our docking program fitted, ...