HL-43
Names
[ CAS No. ]:
2287258-85-7
[ Name ]:
HL-43
Biological Activity
[Description]:
HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity;HL-43 exhibits the highest potency in inducing Col2a1 expression and reducing Mmp3 expression in presence of IL-1β.HL-43 downregulats Mmp3/13 expression in a dose-dependent manner.HL-43 induces anabolic factors (ACAN and SOX9), and suppresses catabolic factor (MMP13), and hypertrophic marker (COLX), inhibits the STAT3 catabolic pathway;.HL-43 promotes chondrocyte differentiation and ECM generation, and inhibits matrix degradation in both human and mouse articular cartilage explants.HL-43 enhances cartilage repair and regeneration in different artilage defect (CD) animal models.
[References]
1. Yunyun Jin, et al. Cell Discov. 2022 Mar 8;8(1):24.
Chemical & Physical Properties
[ Molecular Formula ]:
C26H23FN4O4
[ Molecular Weight ]:
474.492