FXR antagonist 1

Names

[ Name ]:
FXR antagonist 1

Biological Activity

[Description]:

FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation of hepatic FXR. FXR antagonist 1 can improve liver steatosis, inflammation and fibrosis in the NASH (non-alcoholic steatohepatitis) model and can be used to study NASH.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₅₉NO₅

[ Molecular Weight ]:
585.87