LEI110(LEI-110

Names

[ Name ]:
LEI110(LEI-110

Biological Activity

[Description]:

LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6); reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in human HepG2 cells; LEI110 is a selective pan-inhibitor of the HRASLS-family of thiol hydrolases (i.e. PLA2G16, HRASLS2, RARRES3 and iNAT).

[References]

References 1. Zhou J, et al. ACS Chem Biol. 2019 Jan 8. doi: 10.1021/acschembio.8b00969. View Related Products by Target Phospholipase

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₃F₃N₂O₃

[ Molecular Weight ]:
456.465

Related Compounds

CD36 (93-110)-Cys
L-681,110 component A2
Influenza HA (110-119)
TL 13-110
Solvent Red 110
Acid Yellow 110
tert-butyl 3-amino-2-(4-fluoro-3-methylphenyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate
N-(5-Methyloxolan-3-yl)prop-2-enamide
6-Cyano-N-[(2R,3R)-2-(1H-pyrazol-5-yl)oxolan-3-yl]pyridine-3-carboxamide
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-(4-(3,4-dimethoxyphenyl)-5-methyl-1H-pyrazol-3-yl)-5-(2-morpholinoethoxy)phenol
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
Methyl 3-amino-4-fluoro-5-(trifluoromethyl)benzoate
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol