Bay 36-7620
Names
Biological Activity
[Description]:
BAY 36-7620 is a potent and noncompetitive antagonist of mGlu1 Receptor (IC50=0.16 μM) with inverse agonist activity. BAY 36-7620 inhibits tumor growth and prolongs the survival of mice with tumors by inhibiting mGlu1 receptor. BAY 36-7620 suppresses AKT phosphorylation in A549 tumors. BAY 36-762 has neuroprotective effect in acute subdural hematoma rat model.BAY 36-7620 is used in non-small cell lung cancer and breast cancer research[1][2][3][4].
[Related Catalog]:
[Target]
mGluR 1:0.16 μM (IC50)
mGluR1a:0.38 μM (IC50)
mGluR2:0.14 μM (IC50)
mGluR 5:0.24 μM (IC50)
[References]
Chemical & Physical Properties
[ Boiling Point ]:
471.861ºC at 760 mmHg
[ Molecular Formula ]:
C19H18O2
[ Molecular Weight ]:
278.35
[ Flash Point ]:
199.799ºC
[ Exact Mass ]:
278.13100
[ PSA ]:
26.30000
[ LogP ]:
3.89170
[ Vapour Pressure ]:
0mmHg at 25°C
[ Index of Refraction ]:
1.633