4-Epitetracycline hydrochloride

Names

[ Name ]:
4-Epitetracycline hydrochloride

[Synonym ]:
4-epi-Tetracycline hydrochloride
4-Epitetracycline hydrochloride
4-Epitetracycline hydrochloride,‘can be used as a secondary standard‘
2,2,2,2-Propanetetracarbonitrile
4-epi-TetracyclineHydrochloride
(4R,4aS,5aS,6S,12aS)-4-(Dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide hydrochloride (1:1)
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4R,4aS,5aS,6S,12aS)-, hydrochloride (1:1)
MFCD00085371
Epitetracycline hydrochloride
Tetracyanomethane

Biological Activity

[Description]:

4-Epitetracycline hydrochloride is an epimer of the antibiotic tetracycline. Epimers of tetracycline form without catalysis and are considered degradation products. 4-Epitetracycline hydrochloride has decreased activity as an antibiotic or a Tet repressor effector but may have stronger toxic effects in animals.

Chemical & Physical Properties

[ Boiling Point ]:
682.8ºC at 760mmHg

[ Melting Point ]:
217ºC

[ Molecular Formula ]:
C₂₂H₂₅ClN₂O₈

[ Molecular Weight ]:
480.896

[ Flash Point ]:
366.7ºC

[ Exact Mass ]:
480.129944

[ PSA ]:
181.62000

[ LogP ]:
1.28790

[ Appearance of Characters ]:
Fine Crystalline Powder | Yellow

[ Index of Refraction ]:
1.74

[ Storage condition ]:
Amber Vial, -20°C Freezer, Under Inert Atmosphere

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ1898250

CHEMICAL NAME :: 2-Naphthacenecarboxamide, 1,4,4a,5,5a,6,11,12a-octahydro-4-(dimethylamino)-1,11 -dioxo-6- methyl-3,6,10,12,12a-pentahydroxy-, 4-epimer, hydrochloride

CAS REGISTRY NUMBER :: 23313-80-6

LAST UPDATED :: 199203

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H24-N2-O8.Cl-H

MOLECULAR WEIGHT :: 480.94

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 7,569,1957

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H361

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
63-36-36/37/38

[ Safety Phrases ]:
36/37/39-26-36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
QJ1898250

[ HS Code ]:
29413000

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