2-Palmitoylglycerol

Names

[ Name ]:
2-Palmitoylglycerol

[Synonym ]:
2-Palmitoylglycerol
2-Palmitoylglycerol,2-Hydroxy-1-(hydroxymethyl)ethylhexadecanoicacidester

Biological Activity

[Description]:

2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

CB1

[In Vitro]

2-Palmitoylglycerol (2-PG) modestly internalizes CB1 receptor on its own at concentrations as low as 300nM. 2-Palmitoylglycerol behaves as a very modest antagonist in depolarization-induced suppression of excitation (DSE)[1].

[References]

[1]. Natalia Murataeva, et al. Where's my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol. Pharmacol Res. 2016 Aug;110:173-180.

Chemical & Physical Properties

[ Density]:
0.969g/cm3

[ Boiling Point ]:
460.6ºC at 760mmHg

[ Melting Point ]:
68-70°C

[ Molecular Formula ]:
C₁₉H₃₈O₄

[ Molecular Weight ]:
330.50300

[ Flash Point ]:
150.8ºC

[ Exact Mass ]:
330.27700

[ PSA ]:
66.76000

[ LogP ]:
4.36410

[ Index of Refraction ]:
1.4434 (estimate)

[ Storage condition ]:
−20°C

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
43

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2915709000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2915709000

[ Summary ]:
2915709000. palmitic acid and its salts and esters. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%