Propanamide,N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-13-(acetyloxy)-7-hydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-2-yl]-2-oxo-,(2S)-
Names
[ CAS No. ]:
23477-98-7
[ Name ]:
Propanamide,N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-13-(acetyloxy)-7-hydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-2-yl]-2-oxo-,(2S)-
[Synonym ]:
Ro 23-0731/000
Bundlin B
Lankacidin C-14-acetat,Lankacidin A
Sedecamicina [Spanish]
Lankacidin A
Takelan
Sedecamycinum [Latin]
Sedecamycin
Antibiotic T-2636 A
Lankacidin C 14-acetate
Sedecamycine [French]
Chemical & Physical Properties
[ Density]:
1.22g/cm3
[ Molecular Formula ]:
C27H35NO8
[ Molecular Weight ]:
501.56900
[ Exact Mass ]:
501.23600
[ PSA ]:
136.07000
[ LogP ]:
2.67940
[ Index of Refraction ]:
1.552
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UZ0800000
- CHEMICAL NAME :
- Pyruvamide, N-(7,13-dihydroxy-1,4,10,19-tetramethyl-17,18-dioxo-1 6-oxabicyclo(13.2.2) nonadeca-3,5,9,11-tetraen-2-yl)-, 13-acetate, (all-E)-(1S,2R,7S,13S,15R,19R)-(-)-
- CAS REGISTRY NUMBER :
- 23477-98-7
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C27-H35-N-O8
- MOLECULAR WEIGHT :
- 501.63
- WISWESSER LINE NOTATION :
- T6-17- A B AOV DV IU KU OU QUTJ C1 E1 HOV1 K1 NQ Q1 SMVV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,229,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,229,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 41,81,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6 gm/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Gastrointestinal - other changes Blood - changes in cell count (unspecified)
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 26,647,1973